Keratin cytoskeletons in epithelial cells of internal organs

Keratin cytoskeletons in epithelial cells of internal organs.

An antiserum against human epidermal keratins was used to detect keratins in frozen sections of various rabbit and human tissues by indirect immunofluorescence. Strong staining was observed in all stratified squamous epithelia (epidermis, cornea, conjunctiva, tongue, esophagus, vagina, and anus), in epidermal appendages (hair follicle, sebaceous gland, ductal and myoepithelial cells of sweat gl...

Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.

Cell migration and invasion are largely dependent on the complex organization of the various cytoskeletal components. Whereas the role of actin filaments and microtubules in cell motility is well established, the role of intermediate filaments in this process is incompletely understood. Organization and structure of the keratin cytoskeleton, which consists of heteropolymers of at least one type...

The keratin-binding protein Albatross regulates polarization of epithelial cells

The keratin intermediate filament network is abundant in epithelial cells, but its function in the establishment and maintenance of cell polarity is unclear. Here, we show that Albatross complexes with Par3 to regulate formation of the apical junctional complex (AJC) and maintain lateral membrane identity. In nonpolarized epithelial cells, Albatross localizes with keratin filaments, whereas in ...

Cytology of Internal Organs

Organs of Internal Secretion

Ten years of work of the East Harlem Health Center in New York are recorded and evaluated in an interesting and enlightening manner. This health center demonstration in coordinated health and welfare work in a defined city area, initiated by the New York chapter of the American Red Cross, was undertaken by the Department of Health and 21 cooperating voluntary agencies of the city. This health c...